Drug interactions
Lopinavir + Saxagliptin-metformin
Severity: Moderate
Lopinavir and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which can markedly raise saxagliptin exposure. Protease inhibitors can also cause insulin resistance and hyperglycemia, which may reduce metformin's effectiveness.
What this interaction means in plain words
Lopinavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4 (raising saxagliptin levels), and protease inhibitors induce insulin resistance.
What to do
Limit the saxagliptin dose to 2.5 mg daily when combined with a strong CYP3A4 inhibitor. Monitor blood glucose and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Lopinavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which can markedly raise saxagliptin exposure. Protease inhibitors can also cause insulin resistance and hyperglycemia, which may reduce metformin's effectiveness.
How serious is the interaction between Lopinavir and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the saxagliptin dose to 2.5 mg daily when combined with a strong CYP3A4 inhibitor. Monitor blood glucose and adjust antidiabetic therapy as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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