Drug interactions
Lopinavir + Sitagliptin
Severity: Moderate
Lopinavir and Sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as lopinavir (usually boosted with ritonavir) can cause insulin resistance and hyperglycemia. This may reduce glycemic control achieved with sitagliptin.
What this interaction means in plain words
Lopinavir and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through protease inhibitor-induced insulin resistance and impaired glucose metabolism.
What to do
Monitor fasting glucose and HbA1c after starting or changing the antiretroviral regimen. Intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Sitagliptin?
MediHelp rates the interaction as moderate. Lopinavir and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as lopinavir (usually boosted with ritonavir) can cause insulin resistance and hyperglycemia. This may reduce glycemic control achieved with sitagliptin.
How serious is the interaction between Lopinavir and Sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting or changing the antiretroviral regimen. Intensify antidiabetic therapy if control worsens.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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