Drug interactions
Lopinavir + Tamsulosin
Severity: Major
Lopinavir and Tamsulosin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir inhibits CYP3A4 and can raise tamsulosin exposure. This may lead to hypotension, dizziness and syncope.
What this interaction means in plain words
Lopinavir and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lopinavir belongs to Anti Virals; Tamsulosin belongs to Genitourinary.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4 metabolism of tamsulosin.
What to do
Avoid concurrent use where possible. If needed, use the lowest tamsulosin dose and monitor orthostatic blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Tamsulosin?
MediHelp rates the interaction as major. Lopinavir and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir/ritonavir inhibits CYP3A4 and can raise tamsulosin exposure. This may lead to hypotension, dizziness and syncope.
How serious is the interaction between Lopinavir and Tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If needed, use the lowest tamsulosin dose and monitor orthostatic blood pressure.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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