Drug interactions
Lopinavir + Terbinafine
Severity: Minor
Lopinavir and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, given with ritonavir, inhibits CYP3A4 and may slightly increase terbinafine exposure. The clinical effect is expected to be small.
What this interaction means in plain words
Lopinavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lopinavir belongs to Anti Virals; Terbinafine belongs to Anti Fungals.
Why it happens
Lopinavir/ritonavir inhibits CYP3A4, a minor pathway of terbinafine metabolism.
What to do
No routine adjustment is required. Monitor for terbinafine adverse effects during extended therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Terbinafine?
MediHelp rates the interaction as minor. Lopinavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lopinavir, given with ritonavir, inhibits CYP3A4 and may slightly increase terbinafine exposure. The clinical effect is expected to be small.
How serious is the interaction between Lopinavir and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor for terbinafine adverse effects during extended therapy.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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