Drug interactions
Lopinavir + Tolazamide
Severity: Moderate
Lopinavir and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can cause insulin resistance and hyperglycemia, which may undermine glycemic control on tolazamide. Pharmacokinetic effects on sulfonylurea levels are unpredictable.
What this interaction means in plain words
Lopinavir and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Tolazamide belongs to Endocrine.
Why it happens
Protease inhibitor-induced insulin resistance, with possible enzyme effects from ritonavir co-formulation.
What to do
Monitor blood glucose and HbA1c after starting or stopping lopinavir. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Tolazamide?
MediHelp rates the interaction as moderate. Lopinavir and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can cause insulin resistance and hyperglycemia, which may undermine glycemic control on tolazamide. Pharmacokinetic effects on sulfonylurea levels are unpredictable.
How serious is the interaction between Lopinavir and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping lopinavir. Adjust the antidiabetic regimen as needed.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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