Drug interactions
Lopinavir + Umeclidinium-vilanterol
Severity: Major
Lopinavir and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which can raise vilanterol exposure. Lopinavir/ritonavir may also prolong QT and PR intervals, so the combination can increase cardiovascular adverse effects such as tachycardia and arrhythmia.
What this interaction means in plain words
Lopinavir and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lopinavir belongs to Anti Virals; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
CYP3A4 inhibition by ritonavir raising vilanterol exposure, with additive QT and beta-adrenergic cardiac effects.
What to do
Monitor heart rate, ECG and potassium, and watch for signs of beta-agonist excess. Consider an alternative bronchodilator not dependent on CYP3A4 metabolism.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Lopinavir and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which can raise vilanterol exposure. Lopinavir/ritonavir may also prolong QT and PR intervals, so the combination can increase cardiovascular adverse effects such as tachycardia and arrhythmia.
How serious is the interaction between Lopinavir and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium, and watch for signs of beta-agonist excess. Consider an alternative bronchodilator not dependent on CYP3A4 metabolism.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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