Drug interactions
Lopinavir + Zafirlukast
Severity: Minor
Lopinavir and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is a CYP3A4 substrate boosted by ritonavir, which is already a strong CYP3A4 inhibitor. Weakly inhibiting zafirlukast is unlikely to add a meaningful increase.
What this interaction means in plain words
Lopinavir and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lopinavir belongs to Anti Virals; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast could slightly reduce lopinavir clearance.
What to do
No dose change needed; continue routine monitoring of lopinavir tolerability and viral response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Zafirlukast?
MediHelp rates the interaction as minor. Lopinavir and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lopinavir is a CYP3A4 substrate boosted by ritonavir, which is already a strong CYP3A4 inhibitor. Weakly inhibiting zafirlukast is unlikely to add a meaningful increase.
How serious is the interaction between Lopinavir and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; continue routine monitoring of lopinavir tolerability and viral response.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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