Drug interactions
Loratadine + Nicardipine
Severity: Minor
Loratadine and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein and CYP3A4 to some degree, so loratadine levels may rise slightly. Loratadine's wide safety margin makes a meaningful clinical effect unlikely.
What this interaction means in plain words
Loratadine and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein and CYP3A4 by nicardipine.
What to do
No dose change is needed. Monitor for drowsiness or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Nicardipine
Frequently asked questions
Can I take Loratadine with Nicardipine?
MediHelp rates the interaction as minor. Loratadine and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits P-glycoprotein and CYP3A4 to some degree, so loratadine levels may rise slightly. Loratadine's wide safety margin makes a meaningful clinical effect unlikely.
How serious is the interaction between Loratadine and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for drowsiness or headache.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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