Drug interactions
Loratadine + Secobarbital
Severity: Minor
Loratadine and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is an inducer of hepatic and intestinal CYP3A4 and may lower loratadine exposure. This could reduce the antihistamine's effectiveness, although loratadine has a wide safety margin. Both drugs can also cause some sedation.
What this interaction means in plain words
Loratadine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases the metabolic clearance of loratadine.
What to do
Monitor for reduced allergy symptom control and increase the dose or switch to a non-CYP3A4-dependent antihistamine such as fexofenadine if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Loratadine with Secobarbital?
MediHelp rates the interaction as minor. Loratadine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secobarbital is an inducer of hepatic and intestinal CYP3A4 and may lower loratadine exposure. This could reduce the antihistamine's effectiveness, although loratadine has a wide safety margin. Both drugs can also cause some sedation.
How serious is the interaction between Loratadine and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced allergy symptom control and increase the dose or switch to a non-CYP3A4-dependent antihistamine such as fexofenadine if efficacy is lost.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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