Drug interactions
Loratadine + Vinblastine
Severity: Minor
Loratadine and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is a P-glycoprotein substrate, and loratadine may weakly inhibit this transporter. A rise in vinca alkaloid exposure is theoretically possible, which could increase myelosuppression or neurotoxicity, but clinical data are lacking.
What this interaction means in plain words
Loratadine and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Vinblastine belongs to Oncology.
Why it happens
Possible P-glycoprotein inhibition by loratadine reduces vinblastine efflux.
What to do
Monitor blood counts and neurological status as per routine chemotherapy care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Vinblastine
Frequently asked questions
Can I take Loratadine with Vinblastine?
MediHelp rates the interaction as minor. Loratadine and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinblastine is a P-glycoprotein substrate, and loratadine may weakly inhibit this transporter. A rise in vinca alkaloid exposure is theoretically possible, which could increase myelosuppression or neurotoxicity, but clinical data are lacking.
How serious is the interaction between Loratadine and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurological status as per routine chemotherapy care.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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