Drug interactions
Lorazepam + Metoclopramide
Severity: Moderate
Lorazepam and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and impaired alertness, and combined use may increase drowsiness and psychomotor impairment. Metoclopramide may also modestly increase benzodiazepine absorption through faster gastric emptying.
What this interaction means in plain words
Lorazepam and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression, with possibly faster benzodiazepine absorption.
What to do
Monitor sedation and counsel against driving or hazardous tasks. Reduce the lorazepam dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lorazepam and Metoclopramide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoclopramide
Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Metoclopramide?
MediHelp rates the interaction as moderate. Lorazepam and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and impaired alertness, and combined use may increase drowsiness and psychomotor impairment. Metoclopramide may also modestly increase benzodiazepine absorption through faster gastric emptying.
How serious is the interaction between Lorazepam and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and counsel against driving or hazardous tasks. Reduce the lorazepam dose if excessive drowsiness occurs.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
