Drug interactions
Lorazepam + Perampanel
Severity: Moderate
Lorazepam and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel causes dose-related somnolence, dizziness and psychomotor slowing, which may be compounded by lorazepam. Impaired coordination and falls are the main concerns, and mood or behavioral effects from perampanel may be harder to assess when sedated.
What this interaction means in plain words
Lorazepam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression from AMPA-receptor antagonism and GABA-A potentiation.
What to do
Titrate perampanel slowly and monitor for sedation, gait disturbance and mood changes. Advise patients not to drive or operate machinery until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Lorazepam with Perampanel?
MediHelp rates the interaction as moderate. Lorazepam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel causes dose-related somnolence, dizziness and psychomotor slowing, which may be compounded by lorazepam. Impaired coordination and falls are the main concerns, and mood or behavioral effects from perampanel may be harder to assess when sedated.
How serious is the interaction between Lorazepam and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate perampanel slowly and monitor for sedation, gait disturbance and mood changes. Advise patients not to drive or operate machinery until tolerance is established.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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