Drug interactions
Lorazepam + Propofol
Severity: Major
Lorazepam and Propofol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines reduce the propofol dose needed for sedation or anesthesia, and together they can cause deeper than intended sedation, hypotension, apnea and airway obstruction. The effect is intensified with rapid administration or in elderly or hemodynamically fragile patients.
What this interaction means in plain words
Lorazepam and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorazepam belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Synergistic GABA-A receptor-mediated CNS and respiratory depression.
What to do
Reduce the propofol dose and titrate slowly to effect, with continuous monitoring of oxygen saturation, ventilation and blood pressure. Ensure airway management equipment and trained staff are available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lorazepam
Other interactions of Propofol
Frequently asked questions
Can I take Lorazepam with Propofol?
MediHelp rates the interaction as major. Lorazepam and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines reduce the propofol dose needed for sedation or anesthesia, and together they can cause deeper than intended sedation, hypotension, apnea and airway obstruction. The effect is intensified with rapid administration or in elderly or hemodynamically fragile patients.
How serious is the interaction between Lorazepam and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the propofol dose and titrate slowly to effect, with continuous monitoring of oxygen saturation, ventilation and blood pressure. Ensure airway management equipment and trained staff are available.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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