Drug interactions
Lorlatinib + Maraviroc
Severity: Moderate
Lorlatinib and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate and its levels fall with inducers. Lorlatinib may therefore compromise antiretroviral efficacy.
What this interaction means in plain words
Lorlatinib and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Maraviroc belongs to Anti Virals.
Why it happens
Lorlatinib induces CYP3A4, increasing maraviroc clearance.
What to do
Monitor HIV viral load and consider maraviroc dose adjustment as per labeling for CYP3A inducers. Check the full antiretroviral regimen for other inhibitors or inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Lorlatinib with Maraviroc?
MediHelp rates the interaction as moderate. Lorlatinib and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 substrate and its levels fall with inducers. Lorlatinib may therefore compromise antiretroviral efficacy.
How serious is the interaction between Lorlatinib and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider maraviroc dose adjustment as per labeling for CYP3A inducers. Check the full antiretroviral regimen for other inhibitors or inducers.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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