Drug interactions
Lorlatinib + Medroxyprogesterone
Severity: Moderate
Lorlatinib and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may reduce medroxyprogesterone exposure through enzyme induction. This could lower contraceptive or therapeutic effectiveness.
What this interaction means in plain words
Lorlatinib and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Lorlatinib induces CYP3A4, increasing medroxyprogesterone metabolism.
What to do
Add a non-hormonal contraceptive method when contraception is needed. Monitor for loss of therapeutic effect when medroxyprogesterone is used for treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Lorlatinib and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may reduce medroxyprogesterone exposure through enzyme induction. This could lower contraceptive or therapeutic effectiveness.
How serious is the interaction between Lorlatinib and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a non-hormonal contraceptive method when contraception is needed. Monitor for loss of therapeutic effect when medroxyprogesterone is used for treatment.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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