Drug interactions
Lorlatinib + Progesterone
Severity: Moderate
Lorlatinib and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may reduce progesterone exposure. Hormonal efficacy, including contraception, may be compromised.
What this interaction means in plain words
Lorlatinib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Progesterone belongs to Endocrine.
Why it happens
Lorlatinib induces CYP3A4, increasing progesterone metabolism.
What to do
Use an effective non-hormonal contraceptive in addition to or instead of hormonal methods. Monitor for breakthrough bleeding or loss of effect if progesterone is used therapeutically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Progesterone?
MediHelp rates the interaction as moderate. Lorlatinib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may reduce progesterone exposure. Hormonal efficacy, including contraception, may be compromised.
How serious is the interaction between Lorlatinib and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive in addition to or instead of hormonal methods. Monitor for breakthrough bleeding or loss of effect if progesterone is used therapeutically.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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