Drug interactions
Lornoxicam + Losartan
Severity: Moderate
Lornoxicam and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can reduce renal prostaglandin synthesis, which blunts the antihypertensive effect of losartan and impairs renal function, especially in older, dehydrated or renally impaired patients. Hyperkalemia and acute kidney injury may result.
What this interaction means in plain words
Lornoxicam and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Losartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin-mediated renal vasodilation combined with angiotensin receptor blockade reduces glomerular filtration and potassium excretion and counteracts blood pressure lowering.
What to do
Monitor serum creatinine, potassium and blood pressure, ensure adequate hydration, and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Losartan?
MediHelp rates the interaction as moderate. Lornoxicam and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can reduce renal prostaglandin synthesis, which blunts the antihypertensive effect of losartan and impairs renal function, especially in older, dehydrated or renally impaired patients. Hyperkalemia and acute kidney injury may result.
How serious is the interaction between Lornoxicam and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and blood pressure, ensure adequate hydration, and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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