Drug interactions
Lornoxicam + Metoprolol
Severity: Moderate
Lornoxicam and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of beta-blockers, particularly with sustained use. NSAIDs may also affect renal function and fluid retention.
What this interaction means in plain words
Lornoxicam and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Metoprolol belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis with sodium and water retention.
What to do
Monitor blood pressure when NSAID therapy is prolonged. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Metoprolol?
MediHelp rates the interaction as moderate. Lornoxicam and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of beta-blockers, particularly with sustained use. NSAIDs may also affect renal function and fluid retention.
How serious is the interaction between Lornoxicam and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAID therapy is prolonged. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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