Drug interactions
Losartan + Nitroglycerin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive hypotension when nitrates are combined with an ARB; may increase risk of dizziness or syncope, especially if volume depleted.
Mechanism of action
Pharmacodynamic: nitrate-mediated vasodilation plus RAAS blockade–mediated vasodilation from losartan.
Clinical management
Start at lower doses and titrate cautiously; monitor BP and symptoms; ensure adequate volume status.
Drug reference
References
- Cozaar (losartan) Prescribing Information — FDA Label
- Nitroglycerin: Drug Interactions — Lexicomp
Frequently asked questions
Can I take Losartan with Nitroglycerin?
The interaction is rated: Moderate. Additive hypotension when nitrates are combined with an ARB; may increase risk of dizziness or syncope, especially if volume depleted.
How serious is the interaction between Losartan and Nitroglycerin?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Losartan and Nitroglycerin managed?
Start at lower doses and titrate cautiously; monitor BP and symptoms; ensure adequate volume status.
Why do Losartan and Nitroglycerin interact?
Pharmacodynamic: nitrate-mediated vasodilation plus RAAS blockade–mediated vasodilation from losartan.
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