Drug interactions
Losartan + Tazemetostat
Severity: Minor
Losartan and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and a CYP3A substrate, and losartan is partly metabolized by CYP3A4. Effects on either drug are expected to be small and not clinically established.
What this interaction means in plain words
Losartan and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Possible CYP3A4 induction by tazemetostat modestly altering losartan metabolism; mechanism for the reverse effect is not established.
What to do
Monitor blood pressure when starting or stopping tazemetostat. No empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Losartan with Tazemetostat?
MediHelp rates the interaction as minor. Losartan and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A4 inducer and a CYP3A substrate, and losartan is partly metabolized by CYP3A4. Effects on either drug are expected to be small and not clinically established.
How serious is the interaction between Losartan and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping tazemetostat. No empirical dose change is needed.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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