Drug interactions
Losartan + Torsemide
Severity: Moderate
Losartan and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an angiotensin receptor blocker with a loop diuretic can cause excessive hypotension and renal function decline, especially in volume-depleted patients. Potassium effects oppose each other, so the net change is unpredictable.
What this interaction means in plain words
Losartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering and reduced glomerular filtration through angiotensin II blockade after diuretic volume depletion; opposing potassium effects.
What to do
Monitor blood pressure, renal function and potassium after initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Torsemide?
MediHelp rates the interaction as moderate. Losartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an angiotensin receptor blocker with a loop diuretic can cause excessive hypotension and renal function decline, especially in volume-depleted patients. Potassium effects oppose each other, so the net change is unpredictable.
How serious is the interaction between Losartan and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium after initiation and dose changes.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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