Drug interactions
Lovastatin + Tazemetostat
Severity: Moderate
Lovastatin and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may lower lovastatin exposure, reducing efficacy. Lovastatin is not a clinically relevant CYP3A4 inhibitor, so the reverse effect is minimal.
What this interaction means in plain words
Lovastatin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing lovastatin metabolism.
What to do
Monitor lipid response and adjust lovastatin dose or change statin if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Lovastatin with Tazemetostat?
MediHelp rates the interaction as moderate. Lovastatin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may lower lovastatin exposure, reducing efficacy. Lovastatin is not a clinically relevant CYP3A4 inhibitor, so the reverse effect is minimal.
How serious is the interaction between Lovastatin and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and adjust lovastatin dose or change statin if efficacy declines.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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