Drug interactions
Lovastatin + Tipranavir
Severity: Contraindicated
Lovastatin and Tipranavir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, and the boosted regimen strongly inhibits CYP3A4, increasing lovastatin exposure. This raises the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Lovastatin and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lovastatin belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Net CYP3A4 inhibition by ritonavir-boosted tipranavir reduces lovastatin clearance.
What to do
Do not use together; switch to a statin less dependent on CYP3A4 such as pravastatin or rosuvastatin. Monitor for muscle symptoms.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Lovastatin with Tipranavir?
MediHelp rates the interaction as contraindicated. Lovastatin and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir is given with ritonavir, and the boosted regimen strongly inhibits CYP3A4, increasing lovastatin exposure. This raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Lovastatin and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; switch to a statin less dependent on CYP3A4 such as pravastatin or rosuvastatin. Monitor for muscle symptoms.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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