Drug interactions
Lovastatin + Vemurafenib
Severity: Moderate
Lovastatin and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-gp and has variable CYP3A4 effects, so lovastatin exposure may change. Increased exposure would raise the risk of myopathy.
What this interaction means in plain words
Lovastatin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein and modulates CYP3A4, altering lovastatin exposure.
What to do
Monitor for muscle pain and CK elevation and consider a lower lovastatin dose or alternative statin if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Lovastatin with Vemurafenib?
MediHelp rates the interaction as moderate. Lovastatin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-gp and has variable CYP3A4 effects, so lovastatin exposure may change. Increased exposure would raise the risk of myopathy.
How serious is the interaction between Lovastatin and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain and CK elevation and consider a lower lovastatin dose or alternative statin if symptoms develop.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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