Drug interactions
Lovastatin + Voriconazole
Severity: Contraindicated
Lovastatin and Voriconazole: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole greatly increases lovastatin exposure, raising the risk of myopathy and rhabdomyolysis. Lovastatin labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Lovastatin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lovastatin belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated lovastatin metabolism.
What to do
Avoid the combination; suspend lovastatin during voriconazole therapy or switch to a statin not dependent on CYP3A4, such as rosuvastatin or pravastatin.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Voriconazole?
MediHelp rates the interaction as contraindicated. Lovastatin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole greatly increases lovastatin exposure, raising the risk of myopathy and rhabdomyolysis. Lovastatin labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Lovastatin and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; suspend lovastatin during voriconazole therapy or switch to a statin not dependent on CYP3A4, such as rosuvastatin or pravastatin.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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