Drug interactions
Loxapine + Methamphetamine
Severity: Moderate
Loxapine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine blocks dopamine receptors, which can oppose methamphetamine effects, and the stimulant may aggravate psychosis. Both drugs can affect heart rate and blood pressure, and loxapine adds sedation that may be masked by the stimulant.
What this interaction means in plain words
Loxapine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine receptors with overlapping cardiovascular effects.
What to do
Monitor psychiatric status, heart rate, and blood pressure, and reassess the need for the stimulant in patients with psychotic illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Methamphetamine?
MediHelp rates the interaction as moderate. Loxapine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine blocks dopamine receptors, which can oppose methamphetamine effects, and the stimulant may aggravate psychosis. Both drugs can affect heart rate and blood pressure, and loxapine adds sedation that may be masked by the stimulant.
How serious is the interaction between Loxapine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric status, heart rate, and blood pressure, and reassess the need for the stimulant in patients with psychotic illness.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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