Drug interactions
Loxapine + Midodrine
Severity: Moderate
Loxapine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has alpha-1 blocking activity that can lower blood pressure and cause orthostatic hypotension, while midodrine is an alpha-1 agonist used to raise blood pressure. Loxapine may therefore partly offset the benefit of midodrine. The sedation point in the older note is of little clinical importance.
What this interaction means in plain words
Loxapine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenergic receptors.
What to do
Monitor supine and standing blood pressure after starting or changing loxapine and adjust the midodrine dose if control is lost. Consider an antipsychotic with less alpha-blockade if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Loxapine with Midodrine?
MediHelp rates the interaction as moderate. Loxapine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has alpha-1 blocking activity that can lower blood pressure and cause orthostatic hypotension, while midodrine is an alpha-1 agonist used to raise blood pressure. Loxapine may therefore partly offset the benefit of midodrine. The sedation point in the older note is of little clinical importance.
How serious is the interaction between Loxapine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure after starting or changing loxapine and adjust the midodrine dose if control is lost. Consider an antipsychotic with less alpha-blockade if hypotension persists.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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