Drug interactions
Loxapine + Tiotropium-olodaterol
Severity: Moderate
Loxapine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has anticholinergic activity that may add to tiotropium and cause dry mouth, constipation, urinary retention, blurred vision and raised intraocular pressure. Olodaterol with loxapine may also have additive cardiovascular effects, including tachycardia.
What this interaction means in plain words
Loxapine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects, with possible additive cardiovascular effects from the beta2-agonist.
What to do
Monitor for anticholinergic effects, especially in older patients or those with glaucoma, prostatic hypertrophy or constipation. Consider ECG monitoring if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Loxapine and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Loxapine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has anticholinergic activity that may add to tiotropium and cause dry mouth, constipation, urinary retention, blurred vision and raised intraocular pressure. Olodaterol with loxapine may also have additive cardiovascular effects, including tachycardia.
How serious is the interaction between Loxapine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in older patients or those with glaucoma, prostatic hypertrophy or constipation. Consider ECG monitoring if other QT-prolonging drugs are present.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
