Drug interactions
Loxapine + Trazodone
Severity: Moderate
Loxapine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and can cause orthostatic hypotension. Loxapine is also an antipsychotic that may prolong QT, and trazodone carries a similar though smaller risk. Combined use can increase drowsiness, dizziness, falls and impaired psychomotor performance.
What this interaction means in plain words
Loxapine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant, alpha-adrenergic blocking and antihistaminic effects.
What to do
Start with low doses and monitor for excess sedation and orthostatic hypotension. Advise patients to avoid driving and alcohol, and check an ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Trazodone?
MediHelp rates the interaction as moderate. Loxapine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and can cause orthostatic hypotension. Loxapine is also an antipsychotic that may prolong QT, and trazodone carries a similar though smaller risk. Combined use can increase drowsiness, dizziness, falls and impaired psychomotor performance.
How serious is the interaction between Loxapine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for excess sedation and orthostatic hypotension. Advise patients to avoid driving and alcohol, and check an ECG if other QT-prolonging risks exist.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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