Drug interactions
Lumacaftor / ivacaftor + Rolapitant
Severity: Moderate
Lumacaftor / ivacaftor and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and can lower rolapitant exposure, reducing antiemetic efficacy.
What this interaction means in plain words
Lumacaftor / ivacaftor and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A4, accelerating rolapitant clearance.
What to do
Monitor for breakthrough nausea and vomiting, and consider an alternative antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Rolapitant?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and can lower rolapitant exposure, reducing antiemetic efficacy.
How serious is the interaction between Lumacaftor / ivacaftor and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting, and consider an alternative antiemetic.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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