Drug interactions
Lumateperone + Posaconazole
Severity: Major
Lumateperone and Posaconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases lumateperone exposure, which may enhance sedation, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Lumateperone and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lumateperone belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces lumateperone metabolism.
What to do
Reduce lumateperone to 10.5 mg daily while on posaconazole. Monitor for sedation and hypotension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Lumateperone with Posaconazole?
MediHelp rates the interaction as major. Lumateperone and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole increases lumateperone exposure, which may enhance sedation, orthostatic hypotension and other adverse effects.
How serious is the interaction between Lumateperone and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 10.5 mg daily while on posaconazole. Monitor for sedation and hypotension.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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