Drug interactions
Lurasidone + Methsuximide
Severity: Moderate
Lurasidone and Methsuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methsuximide commonly causes drowsiness and dizziness, which may be amplified by lurasidone. Its metabolite may also induce CYP3A4, potentially lowering lurasidone levels, and antipsychotics may lower seizure threshold.
What this interaction means in plain words
Lurasidone and Methsuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Methsuximide belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible CYP3A4 induction by methsuximide reducing lurasidone exposure.
What to do
Monitor seizure control, sedation and psychiatric response, and adjust the lurasidone dose if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Methsuximide
- Amisulpride + Methsuximide Moderate
- Amobarbital + Methsuximide Moderate
- Apalutamide + Methsuximide Moderate
- Asenapine + Methsuximide Moderate
- Brexpiprazole + Methsuximide Moderate
- Brivaracetam + Methsuximide Moderate
Frequently asked questions
Can I take Lurasidone with Methsuximide?
MediHelp rates the interaction as moderate. Lurasidone and Methsuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methsuximide commonly causes drowsiness and dizziness, which may be amplified by lurasidone. Its metabolite may also induce CYP3A4, potentially lowering lurasidone levels, and antipsychotics may lower seizure threshold.
How serious is the interaction between Lurasidone and Methsuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control, sedation and psychiatric response, and adjust the lurasidone dose if efficacy declines.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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