Drug interactions
Lurasidone + Midazolam
Severity: Moderate
Lurasidone and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combined use can increase drowsiness and impair psychomotor function. Midazolam is also a CYP3A4 substrate and lurasidone is a CYP3A4 substrate, but no significant pharmacokinetic effect between them is expected.
What this interaction means in plain words
Lurasidone and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and antipsychotic receptor blockade.
What to do
Use a reduced midazolam dose and titrate to effect. Monitor sedation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Midazolam?
MediHelp rates the interaction as moderate. Lurasidone and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combined use can increase drowsiness and impair psychomotor function. Midazolam is also a CYP3A4 substrate and lurasidone is a CYP3A4 substrate, but no significant pharmacokinetic effect between them is expected.
How serious is the interaction between Lurasidone and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced midazolam dose and titrate to effect. Monitor sedation and blood pressure.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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