Drug interactions
Lurasidone + Paliperidone
Severity: Moderate
Lurasidone and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics raises the risk of additive adverse effects including sedation, orthostatic hypotension, extrapyramidal symptoms and hyperprolactinemia. Paliperidone also prolongs QT to a modest degree.
What this interaction means in plain words
Lurasidone and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive dopamine D2 and serotonin receptor antagonism and additive CNS depression.
What to do
Avoid duplicate antipsychotic therapy unless clearly justified; if combined, monitor for movement disorders, sedation, blood pressure and prolactin-related symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Lurasidone with Paliperidone?
MediHelp rates the interaction as moderate. Lurasidone and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics raises the risk of additive adverse effects including sedation, orthostatic hypotension, extrapyramidal symptoms and hyperprolactinemia. Paliperidone also prolongs QT to a modest degree.
How serious is the interaction between Lurasidone and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antipsychotic therapy unless clearly justified; if combined, monitor for movement disorders, sedation, blood pressure and prolactin-related symptoms.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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