Drug interactions
Lurasidone + Perphenazine
Severity: Moderate
Lurasidone and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases the risk of additive sedation, orthostatic hypotension, extrapyramidal symptoms and metabolic effects. Perphenazine is a CYP2D6 substrate and inhibitor, but lurasidone is mainly cleared by CYP3A4, so no meaningful pharmacokinetic effect is expected.
What this interaction means in plain words
Lurasidone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects from dopamine D2 blockade and CNS depression.
What to do
Avoid unnecessary antipsychotic combinations and review the rationale regularly. Monitor for sedation, extrapyramidal symptoms, blood pressure and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Perphenazine?
MediHelp rates the interaction as moderate. Lurasidone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases the risk of additive sedation, orthostatic hypotension, extrapyramidal symptoms and metabolic effects. Perphenazine is a CYP2D6 substrate and inhibitor, but lurasidone is mainly cleared by CYP3A4, so no meaningful pharmacokinetic effect is expected.
How serious is the interaction between Lurasidone and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary antipsychotic combinations and review the rationale regularly. Monitor for sedation, extrapyramidal symptoms, blood pressure and metabolic parameters.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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