Drug interactions
Lurasidone + Promethazine
Severity: Moderate
Lurasidone and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block dopamine receptors and cause sedation, so used together they may increase drowsiness, orthostatic hypotension and extrapyramidal symptoms. Rarely, the combination could contribute to neuroleptic malignant syndrome.
What this interaction means in plain words
Lurasidone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive D2 antagonism, alpha-adrenergic blockade and CNS depression.
What to do
Monitor sedation, blood pressure and movement disorders, and counsel patients about orthostatic dizziness. Use the lowest effective promethazine dose or choose a non-dopamine-blocking antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Promethazine?
MediHelp rates the interaction as moderate. Lurasidone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block dopamine receptors and cause sedation, so used together they may increase drowsiness, orthostatic hypotension and extrapyramidal symptoms. Rarely, the combination could contribute to neuroleptic malignant syndrome.
How serious is the interaction between Lurasidone and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and movement disorders, and counsel patients about orthostatic dizziness. Use the lowest effective promethazine dose or choose a non-dopamine-blocking antiemetic.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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