Drug interactions
Lurasidone + Ribociclib
Severity: Moderate
Lurasidone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase lurasidone exposure, raising the risk of dose-related adverse effects such as sedation, akathisia and parkinsonism. Both drugs can also affect QT interval.
What this interaction means in plain words
Lurasidone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing lurasidone clearance, with possible additive QT prolongation.
What to do
Start lurasidone at a reduced dose and cap the daily dose as for moderate CYP3A4 inhibitors. Monitor ECG and electrolytes and for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Lurasidone with Ribociclib?
MediHelp rates the interaction as moderate. Lurasidone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may increase lurasidone exposure, raising the risk of dose-related adverse effects such as sedation, akathisia and parkinsonism. Both drugs can also affect QT interval.
How serious is the interaction between Lurasidone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lurasidone at a reduced dose and cap the daily dose as for moderate CYP3A4 inhibitors. Monitor ECG and electrolytes and for adverse effects.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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