Drug interactions
Lurasidone + Tapentadol
Severity: Moderate
Lurasidone and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause somnolence and orthostatic hypotension, and combined with an opioid it may deepen sedation and impair coordination. The effect is typically manageable with monitoring.
What this interaction means in plain words
Lurasidone and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression; no significant pharmacokinetic interaction is expected.
What to do
Monitor for excessive drowsiness, dizziness and falls, especially during initiation or dose increases. Lower the opioid dose if sedation becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Tapentadol?
MediHelp rates the interaction as moderate. Lurasidone and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause somnolence and orthostatic hypotension, and combined with an opioid it may deepen sedation and impair coordination. The effect is typically manageable with monitoring.
How serious is the interaction between Lurasidone and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and falls, especially during initiation or dose increases. Lower the opioid dose if sedation becomes problematic.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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