Drug interactions
Lurasidone + Tipranavir
Severity: Contraindicated
Lurasidone and Tipranavir: contraindicated interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, and the combination has complex but net strong CYP3A4 inhibitory effects that can raise lurasidone concentrations. This increases the risk of dose-related adverse effects including sedation and extrapyramidal symptoms. The combination is contraindicated.
What this interaction means in plain words
Lurasidone and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lurasidone belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4-mediated metabolism of lurasidone.
What to do
Avoid the combination; use an alternative antipsychotic or antiretroviral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Lurasidone with Tipranavir?
MediHelp rates the interaction as contraindicated. Lurasidone and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir is given with ritonavir, and the combination has complex but net strong CYP3A4 inhibitory effects that can raise lurasidone concentrations. This increases the risk of dose-related adverse effects including sedation and extrapyramidal symptoms. The combination is contraindicated.
How serious is the interaction between Lurasidone and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative antipsychotic or antiretroviral.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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