Drug interactions
Lurasidone + Torsemide
Severity: Moderate
Lurasidone and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of torsemide. Patients may experience dizziness or falls, particularly when treatment starts.
What this interaction means in plain words
Lurasidone and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Torsemide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotension from alpha-1 adrenergic blockade and diuretic-induced volume depletion.
What to do
Monitor blood pressure and orthostatic symptoms when starting lurasidone, and reduce the diuretic or antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Torsemide?
MediHelp rates the interaction as moderate. Lurasidone and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of torsemide. Patients may experience dizziness or falls, particularly when treatment starts.
How serious is the interaction between Lurasidone and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting lurasidone, and reduce the diuretic or antihypertensive dose if hypotension occurs.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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