Drug interactions
Lurasidone + Ziconotide
Severity: Moderate
Lurasidone and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide, given intrathecally, can cause dizziness, confusion, sedation and psychiatric or cognitive effects. Concurrent lurasidone may add to CNS depression and make neuropsychiatric symptoms harder to evaluate.
What this interaction means in plain words
Lurasidone and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant and neuropsychiatric effects; no pharmacokinetic interaction is established.
What to do
Monitor mental status, sedation and mood closely, especially during ziconotide titration. Reduce or stop the dose of either drug if cognitive or psychiatric symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Lurasidone with Ziconotide?
MediHelp rates the interaction as moderate. Lurasidone and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide, given intrathecally, can cause dizziness, confusion, sedation and psychiatric or cognitive effects. Concurrent lurasidone may add to CNS depression and make neuropsychiatric symptoms harder to evaluate.
How serious is the interaction between Lurasidone and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status, sedation and mood closely, especially during ziconotide titration. Reduce or stop the dose of either drug if cognitive or psychiatric symptoms worsen.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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