Drug interactions
Lurasidone + Zolmitriptan
Severity: Minor
Lurasidone and Zolmitriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics with 5-HT2A antagonism combined with triptans have rarely been associated with serotonin toxicity, but evidence of a clinically meaningful interaction is sparse. The risk appears low.
What this interaction means in plain words
Lurasidone and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic modulation; the mechanism is not firmly established.
What to do
No routine change is needed; advise patients to report agitation, tremor, fever, diarrhea or muscle rigidity promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Lurasidone with Zolmitriptan?
MediHelp rates the interaction as minor. Lurasidone and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antipsychotics with 5-HT2A antagonism combined with triptans have rarely been associated with serotonin toxicity, but evidence of a clinically meaningful interaction is sparse. The risk appears low.
How serious is the interaction between Lurasidone and Zolmitriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise patients to report agitation, tremor, fever, diarrhea or muscle rigidity promptly.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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