Drug interactions
Macimorelin + Mefloquine
Severity: Moderate
Macimorelin and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in QTc, and mefloquine may add to this effect, which raises the risk of torsades de pointes. Because mefloquine has a very long half-life, its effect persists after discontinuation.
What this interaction means in plain words
Macimorelin and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Defer macimorelin testing in patients taking mefloquine, or use an alternative diagnostic test for growth hormone deficiency. If testing is unavoidable, check the ECG and electrolytes first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Mefloquine?
MediHelp rates the interaction as moderate. Macimorelin and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small increase in QTc, and mefloquine may add to this effect, which raises the risk of torsades de pointes. Because mefloquine has a very long half-life, its effect persists after discontinuation.
How serious is the interaction between Macimorelin and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer macimorelin testing in patients taking mefloquine, or use an alternative diagnostic test for growth hormone deficiency. If testing is unavoidable, check the ECG and electrolytes first.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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