Drug interactions
Macimorelin + Oxaliplatin
Severity: Moderate
Macimorelin and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin can prolong the QT interval, and oxaliplatin may contribute additively. This could increase the risk of arrhythmia during the diagnostic test.
What this interaction means in plain words
Macimorelin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT interval prolongation via pharmacodynamic effects.
What to do
Postpone macimorelin testing in patients receiving oxaliplatin or use an alternative growth hormone stimulation test. Check ECG and electrolytes if testing is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Oxaliplatin?
MediHelp rates the interaction as moderate. Macimorelin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin can prolong the QT interval, and oxaliplatin may contribute additively. This could increase the risk of arrhythmia during the diagnostic test.
How serious is the interaction between Macimorelin and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone macimorelin testing in patients receiving oxaliplatin or use an alternative growth hormone stimulation test. Check ECG and electrolytes if testing is unavoidable.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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