Drug interactions
Macimorelin + Paliperidone
Severity: Major
Macimorelin and Paliperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in the QT interval, and paliperidone also prolongs QTc. Using both around a diagnostic test may add to the risk of torsades de pointes.
What this interaction means in plain words
Macimorelin and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Paliperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid giving macimorelin to patients on paliperidone; allow adequate washout of the QT-prolonging drug before testing where clinically feasible, or use an alternative growth hormone stimulation test.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Macimorelin and Paliperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Paliperidone?
MediHelp rates the interaction as major. Macimorelin and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small increase in the QT interval, and paliperidone also prolongs QTc. Using both around a diagnostic test may add to the risk of torsades de pointes.
How serious is the interaction between Macimorelin and Paliperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients on paliperidone; allow adequate washout of the QT-prolonging drug before testing where clinically feasible, or use an alternative growth hormone stimulation test.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
