Drug interactions
Macimorelin + Perphenazine
Severity: Major
Macimorelin and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in the QTc interval, and perphenazine can add to this effect. This raises the risk of torsades de pointes during or after the diagnostic test.
What this interaction means in plain words
Macimorelin and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Hold perphenazine for a sufficient washout before macimorelin testing where clinically safe, or choose another growth hormone stimulation test. Check an ECG if the combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Perphenazine?
MediHelp rates the interaction as major. Macimorelin and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small increase in the QTc interval, and perphenazine can add to this effect. This raises the risk of torsades de pointes during or after the diagnostic test.
How serious is the interaction between Macimorelin and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold perphenazine for a sufficient washout before macimorelin testing where clinically safe, or choose another growth hormone stimulation test. Check an ECG if the combination cannot be avoided.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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