Drug interactions
Macimorelin + Ribociclib
Severity: Major
Macimorelin and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small QT prolongation and ribociclib also prolongs QT, so the combination may raise the risk of torsades de pointes. This is relevant during the diagnostic test.
What this interaction means in plain words
Macimorelin and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Avoid macimorelin testing in patients taking ribociclib, or use an alternative diagnostic test for growth hormone deficiency. If testing is essential, allow ribociclib washout first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Ribociclib?
MediHelp rates the interaction as major. Macimorelin and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small QT prolongation and ribociclib also prolongs QT, so the combination may raise the risk of torsades de pointes. This is relevant during the diagnostic test.
How serious is the interaction between Macimorelin and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing in patients taking ribociclib, or use an alternative diagnostic test for growth hormone deficiency. If testing is essential, allow ribociclib washout first.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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