Drug interactions
Macimorelin + Solifenacin
Severity: Moderate
Macimorelin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin modestly prolongs the QT interval, and solifenacin may add to this. Together they could raise the risk of torsades de pointes.
What this interaction means in plain words
Macimorelin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT interval prolongation.
What to do
Hold solifenacin for an adequate washout before the macimorelin test where clinically possible. Otherwise avoid testing in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Solifenacin?
MediHelp rates the interaction as moderate. Macimorelin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin modestly prolongs the QT interval, and solifenacin may add to this. Together they could raise the risk of torsades de pointes.
How serious is the interaction between Macimorelin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold solifenacin for an adequate washout before the macimorelin test where clinically possible. Otherwise avoid testing in patients with other QT risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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