Drug interactions
Macimorelin + Tacrolimus
Severity: Moderate
Macimorelin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, so combined exposure could raise the risk of torsade de pointes. Macimorelin is a single-dose diagnostic test, so the exposure is brief.
What this interaction means in plain words
Macimorelin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Consider using an alternative diagnostic method for growth hormone deficiency if feasible. If the test is needed, check ECG and electrolytes beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Tacrolimus?
MediHelp rates the interaction as moderate. Macimorelin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents prolong the QT interval, so combined exposure could raise the risk of torsade de pointes. Macimorelin is a single-dose diagnostic test, so the exposure is brief.
How serious is the interaction between Macimorelin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider using an alternative diagnostic method for growth hormone deficiency if feasible. If the test is needed, check ECG and electrolytes beforehand.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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