Drug interactions
Magnesium + Metolazone
Severity: Moderate
Magnesium and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone increases urinary magnesium excretion and can cause hypomagnesemia, particularly when combined with loop diuretics. This may worsen potassium depletion and arrhythmia risk.
What this interaction means in plain words
Magnesium and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium belongs to Gastrointestinal Tract; Metolazone belongs to Cardiovascular.
Why it happens
Inhibition of distal tubular sodium-chloride transport reduces magnesium reabsorption.
What to do
Monitor serum magnesium and potassium, especially with combined diuretic therapy, and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Metolazone
Frequently asked questions
Can I take Magnesium with Metolazone?
MediHelp rates the interaction as moderate. Magnesium and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone increases urinary magnesium excretion and can cause hypomagnesemia, particularly when combined with loop diuretics. This may worsen potassium depletion and arrhythmia risk.
How serious is the interaction between Magnesium and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium, especially with combined diuretic therapy, and replace as needed.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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